Hi Mario,
I think the 53C80 might be the newer part. My design was done in 1991, I think I interchangeably used a national part and the zilog part. I never used the 53C80, because it's pined out differently, but the registers and programming all look the be the same. The device can be operated in both initiator and target mode so it seems usable for your application. I assume you are wanting to replace old SCSI hard drives with this device and use compact flash as the storage device? if so, have you considered using SD flash rather than CF? I have used a lot of CF on products that had a Z80380 CPU, and they proved to be a bit problematic.
Here is a link to the national/TI flavor of the Z0538010PSC
www.ti.com/lit/ds/symlink/dp5380.pdf
I could probably dig up the source code for the drivers I did for this part if you think they might help you, but they are in 80180 (Z80ish) assembler and 20 years old.